Thealoz Duo Eye Drops - Rapid & Long-Lasting Relief for Dry, Tired & Sore Eyes | Gentle, Preservative-Free Formula | Suitable for Contact Lens Wearers | 10 ml (300 Drops)

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The primary endpoint was analyzed using a mixed-effects analysis of covariance, considering the patient within the sequence as a random effect and using the type III Sum of Squares for evaluation of the effect. For these reasons, sodium hyaluronate has long been used for managing dry eyes. However, Thealoz Duo offers unique dry eye management properties by combining this substance with trehalose. How Trehalose and Sodium Hyaluronate Work Together in Thealoz Duo The study was a single center randomized, open label, crossover trial. Thealoz Duo ® was compared with an active control Systane ®, an established and effective treatment in dry eye. In one study, 62% of patients receiving Thealoz Duo were symptom free after 84 days, with significant improvements in blurred vision, stinging and itching. This study indicates that patient satisfaction improved with both Thealoz Duo ® and Systane ® although Thealoz Duo ® resulted in significantly greater improvement in patient satisfaction than did Systane ®. On secondary efficacy variables, Thealoz Duo ® was at least as effective as Systane ® on secondary efficacy variables: OSDI, staining, ocular signs, Schirmer/BUT, patient satisfaction/global efficacy (patient and investigator), and patient preference. Moreover, there was a significant advantage for Thealoz Duo ® in dry eye symptoms on impact on work. However, this was a relatively small study, and the duration of treatment was relatively short, which likely explains the inconsistency between the results on some parameters. Although some parameters (OSDI, for example) did not show statistically significant differences between the two treatments, the direction of the trends between the treatments was consistent; where statistically significant differences were observed between the treatments, they were all in favor of Thealoz Duo ®.

A growing amount of research suggests that trehalose can help protect cells in the eye from hyperosmolarity. Hyperosmolarity is a major contributing factor to numerous dry eye symptoms, including inflammation.Dry eyes can be either natural, generic (passed down from family members with eye problems) or environmental depending on the health of your eyes. Dry eyes can be caused by the following natural, generic or environmental situations: Overall global efficacy was assessed by both patient and investigator at the end of each treatment period. The investigator assessed efficacy on a four-point scale (0= “very satisfactory” to 3= “unsatisfactory”). The patient assessed efficacy in the domains of effectiveness (nine questions) and inconvenience (three questions). Every individual question was scored from 0 (greatly disagree) to 3 (greatly agree). The sum of all the individual scores provided the global score of effectiveness and inconvenience.

KOOSTUMUS: Trehaloosia (3 %), natriumhyaluronaatti (0,15 %), natriumkloridi, trometamoli, kloorivetyhappo ja injektionesteisiin käytettävä vesi. There are no known side effects to using Thealoz Duo eye drops or concerning reports from users. These drops are completely sterile and only use preservative free lubricants in its ingredients which do not cause any further irritation to your eyes. Thealoz Duo ® (Laboratoires Théa, Clermont Ferrand, France) is an artificial tear preparation containing two active ingredients: trehalose, a naturally occurring disaccharide of glucose that appears to function in an anhydrobiotic capacity in many organisms, and hyaluronate, a widely distributed anionic glycosaminoglycan polysaccharide with biological roles associated with its lubricative and water-retaining properties. Trehalose has been shown not only to stabilize both bilipid membranes and labile proteins against desiccation, but also to have a protective effect against desiccation and oxidative insult in the mammalian eye. 4 Hyaluronate is a component of many medicinal preparations including those used in cataract surgery, for the treatment of dry eye as well as many commercial skin preparations and antiaging creams. 5 It is also present in natural human tears. 6The following sections break down exactly how each of the two primary ingredients (Trehalose and Sodium Hyaluronate) in Thealoz Duo eye drops helps alleviate dry eye symptoms. How Trehalose Works in Thealoz Duo Eye Drops Thealoz® Duo dry eye drops are suitable for all dry eye sufferers looking for the latest drop. They contain a unique combination of ingredients (trehalose plus sodium hyaluronate) that deliver long-lasting symptom relief(1) and protection for the surface of the eye. A randomized crossover study comparing trehalose/hyaluronate eyedrops and standard treatment: patient satisfaction in the treatment of dry eye syndrome - PMC Dry Eye means that your eyes may not be making enough tears, the tears you are making are of poor quality or evaporate faster than they should.

The liquid gel drops come in easy to squeeze single dose vial, A drop can be applied as often as necessary throughout the day contains 30 single-use unit doses. Once the vial has been opened throw away, even if there is a small amount left, do not reuse. Once opened the microbial protection of the solution cannot be guaranteed. Trehalose-containing eyedrops have previously been shown to be effective in in vitro, 9, 10 ex vivo, 11 and in vivo animal studies 12 as well as in a few clinical studies. 13– 15 A further advantage of this formulation is a longer residency time than hyaluronate alone, as recently shown in a randomized, double-masked study. 16 Clinical studies have investigated the use of trehalose in eyedrops with positive results. These larger studies established significant benefits of trehalose-containing eyedrops over saline and hydroxymethylcellulose eyedrops. 13, 14 The utility of hyaluronate-containing eyedrops is well established in the treatment of dry eye. 17– 22 Thealoz Duo combines both trehalose and sodium hyaluronate for potent dry eye relief. One study found that approximately 62% of patients using Thealoz Duo experienced no significant symptoms of dry eyes after 84 days. The following symptoms were evaluated as part of the study: Clinically proven to stabilize tear film, reduce inflammatory markers and restore normal osmotic balance.The most widely used preservative-free bottle in the world. In one study, 62% of patients receiving Thealoz Duo were symptom free after 84 days Sodium hyaluronate adds moisture by retaining water to hydrate and lubricate the surface of the eye To help reduce or eliminate these symptoms, Thealoz Duo works in several ways due to the active ingredients Trehalose (as in Thealoz) and Sodium Hyaluronic Acid (also known as Hyabak). It is also free from preservatives. Palpebral signs including meibomitis and other blepharitis, conjunctival discharge, chemosis, folliculo-papillary conjunctivitis, filamentary keratitis, and other relevant ocular signs were evaluated in each eye at days 0, 7, 12, and 19. Palpebral signs were evaluated on a four-point scale (0= none, 1= mild, 2= moderate, 3= severe).