Joined in 2023 
82 
63 About this deal
The Phase I/II clinical trial in China is a randomized, double-blind, placebo-controlled clinical study to evaluate the safety, tolerability, pharmacokinetics, and efficacy of Pyrilutamide in patients with mild to moderate acne vulgaris. Hirshburg, J. M., Kelsey, P. A., Therrien, C. A., Gavino, A. C., & Reichenberg, J. S. (2016). Adverse effects and safety of 5-alpha reductase inhibitors (finasteride, dutasteride): a systematic review. The Journal of clinical and aesthetic dermatology, 9(7), 56. I believe it's currently undergone Phase 2 trials in both the US and China, heading towards the final stages. I would be seriously interested to see if there's any chance whatsoever that when DHT bindings at the Androgen Receptor are cut, whether even people with "dead zones" usually considered past the 50% point of miniaturisation might show regrowth with this new or combined treatments. COVID-19 has caused significant interference to our business and the COVID-19 intelligence from GlobalData has helped us reach better decisions around strategy. These two highlights have helped enormously to understand the projections into the future concerning our business units, we also utilise the project database to source new projects for Liebherr-Werk to use as an additional source to pitch for new business.”
Pyrilutamide vs RU58841? Or use both concurrently? Pyrilutamide vs RU58841? Or use both concurrently?
KX-826 is an androgen receptor antagonist and a potential first-in-class topical drug for the treatment of AGA and acne vulgaris. The primary endpoint of the phase II clinical trial of KX-826 on adult male patients was met, as results showed good efficacy and safety profile. Pyrilutamide is a topical anti-androgen. The clinical trials done so far have shown that it does not decrease systemic androgen levels. Thus, it is unlikely to cause unwanted adverse drug reactions that are usually seen in patients using oral 5-alpha reductase inhibitors – decreased libido, erectile dysfunction, and depression being the most notable ones. I did some reading. So this is topical? How much is the systemic absorption? I would not take an anti androgen orally as a male. It would have a castrating effect. If topical, biggest worry and need to know would be plasma concentration. it would work similar to topical spironolactoneEverybody generally seems to mention 1mm to 1.5mm once a week as a sufficient depth. Some people may have a more sensitive scalp and/or need to build a tolerance so really it's whatever is more comfortable for you. In terms of saving hair or regrowth, almost no treatment out there guarantees that. It just so happens we have anecdotal evidence that people using the "Big 3" of Finasteride, Minoxodil and Microneedling with perhaps a side of Nizoral containing 2% ketoconazole have shown regrowth. So there's a possibility this could help too but from a legal and marketing PoV, it's better to protect themselves by not saying that's a benefit of the product. KX-826 (pyrilutamide) is a monoclonal antibody drug candidate with potential AR antagonistic action, is being developed as a potential topical drug for the treatment of androgenic alopecia and acne vulgaris. cyano-2-fluoro-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro- N-methylbenzamide
Pyrilutamide - Wikipedia
The GlobalData platform is our go-to tool for intelligence services. GlobalData provides an easy way to access comprehensive intelligence data around multiple sectors, which essentially makes it a one-for-all intelligence platform, for tendering and approaching customers.Pyrilutamide is an androgen receptor antagonist that prevents dihydrotestosterone (DHT) from binding to its receptors in hair follicles. This prevents the effects of androgens on the hair follicle, such as miniaturization and eventual hair loss.
Pyrilutamide - A Game Changer In the Making? - Hair Pyrilutamide - A Game Changer In the Making? - Hair
Personally i'm willing to give it a go when it's fully approved if its cheap enough but only alongside my current regimen. A total of 160 female AGA patients who have met Savin Scale (D3-D6) were enrolled in the phase II clinical trial, with 119 patients randomly assigned to four treatment groups. Pivotal study A derma pen from experience feels different even at 1mm to say a derma roller and that's why it's sometimes best to start off with a depth that's not causing you too much discomfort. Saceda-Corralo D, Domínguez-Santas M, Vañó-Galván S, Grimalt R (January 2023). "What's New in Therapy for Male Androgenetic Alopecia?". American Journal of Clinical Dermatology. 24 (1): 15–24. doi: 10.1007/s40257-022-00730-y. PMID 36169916.Pyrilutamide (KX-826) is under development for the treatment of androgen associated alopecia and acne vulgaris.The drug candidate is for external use and administered through topical route. It acts by targeting androgen receptor. It was also under development for the treatment of whelk and diabetic foot ulcer. Honestly any new drugs on the market and i'd expect this happens quite often and even is considered par for the course. Right now, joining a pyrilutamide clinical trial is highly unlikely as enrollment for men in the United States and women in China are currently closed. You’d only be considered as a participant if you were a man with moderate pattern hair loss symptoms living in China.
Great Deal 
New Comment