Cranberry Capsules 35,000mg High Strength - with Probiotics/Bio Cultures and Vitamin C - 150 Capsules - Advanced Cranberry Extract Supplement - Made in UK by VitaBright

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Maki KC, Kaspar KL, Khoo C, Derrig LH, Schild AL, Gupta K. Consumption of a cranberry juice beverage lowed the number of clinical urinary tract infection episodes in women with a recent history of urinary tract infection. Am J Clin Nutr. 2016 Jun;103(6):1434-42. View abstract. Conquy, S. [Cranberries for preventing urinary tract infections?]. Prog Urol 2006;16(4 Suppl FMC):3-4. View abstract. Kinney AB, Blount M. Effect of cranberry juice on urinary pH. Nurs Res 1979;28:287-90. View abstract.

Probiotics as Prophylaxis for Urinary Tract Efficacy of Probiotics as Prophylaxis for Urinary Tract

Pourmasoumi M, Hadi A, Najafgholizadeh A, Joukar F, Mansour-Ghanaei F. The effects of cranberry on cardiovascular metabolic risk factors: a systematic review and meta-analysis. Clin Nutr 2020;39(3):774-88. View abstract. Lee YL, Owens J, Thrupp L, Cesario TC. Does cranberry juice have antibacterial activity? JAMA 2000;283:1691. View abstract.Another variable that may partially explain the result of our review is the inclusion of only adult premenopausal women (i.e., 18 to 50). The literature on rUTIs in premenopausal women suggests that the risk factors in this age group differ from those in the postmenopausal age group [ 41]. Premenopausal women are more likely to have recent antibiotic use, an individual history of UTIs, use of an intrauterine device, use of spermicidal condoms, and recent sexual intercourse [ 6]. These risk factors have an indeterminate level of impact on the ratio of uropathogens to protective microorganisms in this population and are not entirely controlled for in most published studies. Perhaps more importantly is the composition of the female bladder microbiota pre- and post-menopause. Antonio et al. have demonstrated that postmenopausal women have 25% to 30% of the LB in the vagina compared to premenopausal women [ 16]. Other researchers have also demonstrated that estrogen therapy may increase this percentage of vaginal LB to 60-100% [ 42]. Because premenopausal women do not appear to be as deficient in beneficial LB, our impression is that premenopausal women may not experience as much benefit from supplemental probiotics containing LB. The findings of Uehara et al. support this notion as they have demonstrated a significant reduction in the number of UTI recurrences in postmenopausal women treated with intravaginal probiotics [ 36]. Along with implementing standardized bacterial strains, future researchers may aim to administer probiotics via routes that have proven to effectively colonize the vagina, bladder, and urogenital tract. Differences in beneficial and uropathogenic microorganisms have been observed between healthy populations and those with frequent UTIs. Quantities of beneficial urinary microorganisms, such as Lactobacillus and Bifidobacterium, have been shown to be decreased in patients with predisposing risk factors for UTI. Particular species of lactobacilli (LB), namely, Lactobacillus iners, Lactobacillus crispatus, and Lactobacillus jensenii,have been found to predominate in healthy premenopausal women [ 16- 18]. Moreover, intravaginal estrogen, a well-studied and effective form of non-antibiotic prophylaxis for UTI in postmenopausal women, has been shown to increase the concentrations of LB in the vagina [ 19]. The proposed mechanism is primarily through the acidification of the vaginal canal. LB are lactic acid-producing bacteria and their presence results in a decrease in vaginal pH. This decrease in vaginal pH thwarts the growth of microorganisms and has been found to have a protective effect against UTI recurrence [ 20]. More recent literature has added to this paradigm by revealing similarities in vaginal and bladder microbiota [ 14]. On the basis of these research findings in tandem, supplementation with microorganisms (probiotics) is theorized to promote colonization of protective microbes and play a role in UTI prophylaxis and the maintenance of urinary health. Thus, probiotics have been proposed as a non-pharmaceutical option for UTI prophylaxis. Multiple studies have evaluated the efficacy of these beneficial microorganisms in the context of UTI prophylaxis [ 21- 23]. Weiss, E. I., Houri-Haddad, Y., Greenbaum, E., Hochman, N., Ofek, I., and Zakay-Rones, Z. Cranberry juice constituents affect influenza virus adhesion and infectivity. Antiviral Res. 2005;66(1):9-12. View abstract.

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Labrecque, J., Bodet, C., Chandad, F., and Grenier, D. Effects of a high-molecular-weight cranberry fraction on growth, biofilm formation and adherence of Porphyromonas gingivalis. J Antimicrob.Chemother. 2006;58(2):439-443. View abstract. Jepson RG, Mihaljevic L, Craig J. Cranberries for treating urinary tract infections. Cochrane Database Syst Rev 2004;2:CD001322. View abstract. Zhang, L., Ma, J., Pan, K., Go, V. L., Chen, J., and You, W. C. Efficacy of cranberry juice on Helicobacter pylori infection: a double-blind, randomized placebo-controlled trial. Helicobacter. 2005;10(2):139-145. View abstract.Epp, A., Larochelle, A., Lovatsis, D., Walter, J. E., Easton, W., Farrell, S. A., Girouard, L., Gupta, C., Harvey, M. A., Robert, M., Ross, S., Schachter, J., Schulz, J. A., Wilkie, D., Ehman, W., Domb, S., Gagnon, A., Hughes, O., Konkin, J., Lynch, J., Marshall, C., and Society of Obstetricians and Gynaecologists of Canada. Recurrent urinary tract infection. J Obstet Gynaecol Can. 2010;32(11):1082-1101. View abstract. Dohadwala, M. M., Holbrook, M., Hamburg, N. M., Shenouda, S. M., Chung, W. B., Titas, M., Kluge, M. A., Wang, N., Palmisano, J., Milbury, P. E., Blumberg, J. B., and Vita, J. A. Effects of cranberry juice consumption on vascular function in patients with coronary artery disease. Am.J Clin.Nutr 2011;93(5):934-940. View abstract.