Healthspan Vein Vine 360mg (90 Tablets) | for Tired & Heavy Legs | Maintains Healthy Leg-Vein Functions | Red Vine Leaf Extract | Added Vitamins B1 & C | Vegan

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Kalus, U. et al (2004) Improvement of cutaneous microcirculation and oxygen supply in patients with chronic venous insufficiency by orally administered red vine leaves AS 195: a randomised, double-blind, placebo-controlled, crossover study. Drugs and RD; 5: 2, 63-71. Nees et al (2003) undertook an in vitro study to increase understanding of the effects of endothelial inhibitors and to explore the possible role of venular endothelial cells in the development of connective tissue failure characteristically seen in CVI. It was discovered that a standardised extract of red vine leaves (AS 195) not only protected venular endothelial cells but also, when applied to previously damaged cells, could prompt cellular repair. Safety: Our treatments have proven 99%+ safe over the last 12+ years (with minor/temporary irritation occurring in the other 1%- of treatments). However,as with any medical/aesthetic treatment or skin product,sensitivity varies from person to person, and from time to time even on the same person, depending on lifestyle, genetics and state of health(how each individual body responds to a treatment at a specific time), so we cannot guarantee 100% safety.

The dried aqueous extract of standardised red vine leaves (AS 195) is a food supplement available in capsules. Red vine leaf extract has been available in France for the treatment of symptoms associated with venous insufficiency. In the UK it is sold as a dietary supplement for the maintenance of healthy leg-vein circulation, in particular to avoid tired, heavy and aching legs that result from long periods of standing or sitting.

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Other studies found similar reductions in calf swelling, sensations of heaviness and pain from taking red vine leaf extracts. Red vine leaf and venous thrombosis Schaefer, E. et al (2003) Oedema-protective properties of the red vine leaf extract AS 195 (folia vitis viniferae) in the treatment of chronic venous insufficiency: a 6-week observational clinical trial. Arzneimittelforschung; 53: 4, 243-246. There are dozens of studies on the effects of red vine leaf extract, a natural traditional medicine used to treat symptoms of CVI in Continental Europe for several decades No AI tool has the depth of experience accumulated over tens of thousands of sessions with real human beings (in fact, AI tools have zero experience, obviously). Neither can an AI tool discriminate what is reality and what is made up BS on the web. It is caused by too much pressure in the veins of the legs, causing them to be hypertensive. This causes a stasis in the lower leg. The effect of this is painful lower legs that are characterized by swelling. The condition can progress to become more chronic if left untreated, and you could ultimately develop leg ulcers. About Red Vine Leaf Extract

One of the first studies to assess the effectiveness of red vine leaf extracts (Antistax) asked 71 people with leg swelling (due to chronic venous insufficiency) to take 360mg red vine leaf extracts, or placebo during two separate periods of 6 weeks. This meant that each person tried both treatments and acted as their own controls. This was followed by another study, involving 248 patients with more severe chronic venous insufficiency, classed as moderate-to-severe. Half took 720 mg red vine leaf extract per day for 12 weeks, while half took inactive placebo. The red vine leaf extract significantly reduced lower limb volume by 20 ml more than placebo (27ml versus 7ml) with an associated decrease in leg pain. Research paper abstract: “Aim: Chronic venous insufficiency (CVI) is common in adults. Some complications include skin changes, edema, heavy legs, muscle cramps, pain, and varicose veins. In traditional medicine, red vine leaf extract (AS 195) has been used to cure the symptoms of CVI. This systematic review was aimed to assess the effects of AS 195 in patients with CVI. Material and methods: A systematic literature search was performed to identify trials that reported the impact of red vine leaf extract on CVI. The primary outcomes investigated were Leg (limb) volume, calf circumference, ankle circumference, tired and heavy legs, a sensation of tension, tingling sensation, and pain. Results: From the 56 studies, 5 trials were selected according to our inclusion criteria. Red vine leaf extract significantly improved numbers of outcomes (lower leg volume, calf and ankle circumference, tired, heavy legs, tingling sensation, pain, the sensation of tension in the legs, cutaneous microcirculation, and transcutaneous oxygen pressure) in only some trials. The tolerability for red vine leaf extract was reported good or satisfactory. Conclusions: Red vine leaf extract had a beneficial therapeutic role in patients with CVI. Further high‐quality trials are required to be carried out to provide strong evidence.“ According to those studies, oral intake of red vine leaf extract significantly improved all the above clinical outcomes, namely lower leg volume, calf and ankle circumference, tired/heavy legs, tingling sensation, pain, tension sensation in the legs.

Vine leaf extract might sound like a weird remedy for CVI. However, it is more effective than it sounds. It is extracted from grapevines and can be considered the cousin of red wine. You might be aware of the incredible benefits of red wines due to their resveratrol property. The wine is not the only nutritious and healing part of the vine. The leaves are also considered a good source of the most powerful and fully natural compound to come out of a vine. The extract contains a number of bioflavonoids including flavone/flavonol glycosides and glucuronides, in particular quercetin-3-O-b-D-glucuronide, isoquercitrin and kaempferol-3-glucoside. It is registered as an over-the-counter medicine in several European countries. What evidence is available for its use?

A source of flavonoids that has undergone extensive preclinical and clinical investigation is the red vine leaf extract AS 195. This has shown that its flavonoids may have significant benefits for patients with pre-ulcer venous hypertension. Red vine leaf extract AS 195Oduncu, H. et al (2004) Effects of compression on blood flow in lower limb wounds. International Wound Journal; 1: 2, 107-113. Red vine leaves are also photoprotective. They function to protect the skin from harmful radiation. Recent studies have investigated the action of flavonoids in preventing atherosclerotic plaques (Hollman and Katan, 1997). Bioflavonoids or flavonoids are a class of water-soluble substances found in a number of plants or plant-derived products. It is believed that flavonoids have a wide range of beneficial effects when taken in the diet, including anti-inflammatory, antihistaminic and antiviral action. Formica and Regelson (1995) concluded that flavonoids are important in the maintenance of capillary wall integrity and resistance.

The usual dose is 360 mg to 720 mg daily, but follow manufacturer’s instructions as the concentration of red vine leaf extracts vary. Only select supplements made to a pharmaceutical standard known as GMP, as low quality red vine leaf products (on sale in health food shops in Japan) were found to contain low levels of active polyphenols, and inconsistent levels per tablet.The researchers concluded that adding angioprotectors ( red vine leaf extract) to standard medical treatment helps to correct endothelial dysfunction (the ability of veins to recover and dilate) and may improve the immediate results for patients with acute venous thrombosis. Red vine leaf dose