Molecular Biology of the Cell

Product Information

Initial Patterns Are Established in Small Fields of Cells and Refined by Sequential Induction as the Embryo Grows Two Proteins That Repress Each Other's Synthesis Determine the Heritable State of Bacteriophage Lambda

A Strand-directed Mismatch Repair System Removes Replication Errors That Escape from the Replication Machine By skillfully extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and thereby create a coherent framework through which readers may approach and enjoy this subject that is so central to all of biology. Epithelial Cells Have Two Distinct Early Endosomal Compartments But a Common Late Endosomal CompartmentA comparison of the cell cycles of fission yeasts and budding yeasts. (A) The fission yeast has a typical eucaryotic cell cycle with G 1, S, G 2, and M phases. In contrast with what happens in higher eucaryotic cells, however, the nuclear envelope of the (more...) How photosynthesis occurs – collection of the infalling light inside the chloroplast, conversion of the photon’s energy into a resonant state of the chlorophyll and its transfer from the antenna complex to the reaction center, where a weak electron donor is promoted to a strong one. Dissociated Vertebrate Cells Can Reassemble into Organized Tissues Through Selective Cell-Cell Adhesion Expression of a Critical Gene Regulatory Protein Can Trigger Expression of a Whole Battery of Downstream Genes

Oocyte growth and egg cleavage in Xenopus. The oocyte grows without dividing for many months in the ovary of the mother frog and finally matures into an egg. Upon fertilization, the egg cleaves very rapidly—initially at a rate of one division (more...) Mammalian cells occasionally undergo mutations that allow them to proliferate readily and indefinitely in culture as “immortalized” cell lines. Although they are not normal, such cell lines are used widely for cell-cycle studies—and for cell biology generally—because they provide an unlimited source of genetically homogeneous cells. In addition, these cells are sufficiently large to allow detailed cytological observations of cell-cycle events, and they are amenable to biochemical analysis of the proteins involved in cell-cycle control. Now in it’s 6th edition, Molecular Biology of the Cell(MBoC), a classic university biology textbook, and it’s lighter companion book, Essential Cell Biology (in its 4th edition), continue to offer students a “new and invigorating outlook on what cells are and what they do.” Sexual Reproduction Gives a Competitive Advantage to Organisms in an Unpredictably Variable EnvironmentNotch Signaling Regulates the Fine-Grained Pattern of Differentiated Cell Types in Many Different Tissues The Primary Cell Wall Is Built from Cellulose Microfibrils Interwoven with a Network of Pectic Polysaccharides Combinations of Start-Transfer and Stop-Transfer Signals Determine the Topology of Multipass Transmembrane Proteins Cytotoxic T Cells Recognize Fragments of Foreign Cytosolic Proteins in Association with Class I MHC Proteins

As Electrons Move Along the Respiratory Chain, Energy Is Stored as an Electrochemical Proton Gradient Across the Inner MembraneThe Normal Gene in a Cell Can Be Directly Replaced by an Engineered Mutant Gene in Bacteria and Some Lower Eucaryotes Filament Treadmilling and Dynamic Instability Are Consequences of Nucleotide Hydrolysis by Tubulin and Actin

Comparisons Between the DNAs of Related Organisms Distinguish Conserved and Nonconserved Regions of DNA Sequence Mammalian cells proliferating in culture. The cells in this scanning electron micrograph are rat fibroblasts. (Courtesy of Guenter Albrecht-Buehler.) Protein Transport into the Inner Mitochondrial Membrane and the Intermembrane Space Requires Two Signal Sequences Molecular Biology of the Cell, Sixth Edition: The Problems Book by John Wilson and Tim Hunt The Problems Book is designed to help students appreciate the ways in which experiments and simple calculations can lead to an understanding of how cells work. It provides problems to accompany Chapters 1–20 of Molecular Biology of the Cell. Each chapter of problems is divided into sections that correspond to those of the main textbook and review key terms, test for understanding basic concepts, pose research-based problems, and now include MCAT-style questions which help students to prepare for standardized medical school admission tests. Molecular Biology of the Cell, Sixth Edition: The Problems Book should be useful for homework assignments and as a basis for class discussion. It could even provide ideas for exam questions. Solutions for all of the problems are provided in the book. Solutions for the end-of-chapter problems for Chapters 1–24 in the main textbook are also found in The Problems Book For nearly a quarter century Molecular Biology of the Cell has been the leading cell biology textbook. This tradition continues with the new Fifth Edition, which has been completely revised and updated to describe our current, rapidly advancing understanding of cell biology. To list but a few examples, a large amount of new material is presented on epigenetics; stem cells; RNAi; comparative genomics; the latest cancer therapies; apoptosis (now its own separate chapter); and cell cycle control and the mechanics of M phase (now integrated into one chapter).Proteins That Bind to the 5′ and 3′ Untranslated Regions of mRNAs Mediate Negative Translational Control