MY BATTLE AGAINST CANCER: Survivor protocol : foreword by Thomas Seyfried

Product Information

Rothemberg, M.L.; Nelson, R.; Hande, K.R. New drugs on the horizon: Matrix MetalloproteinaseInhibitors. Stem. Cells 1999, 17, 237–240. [ Google Scholar] [ CrossRef] [ PubMed] Halestrap, A.P. The Monocarboxylate Transporter Family—Structure and Functional Characterization. IUMB Life 2012, 64, 1–9. [ Google Scholar] [ CrossRef]

The production of ketone bodies in the liver requires the mobilization of lipid stores; catabolic hormones trigger lipolysis, which provides fatty acids. These acids enter mitochondria through a carnityl-driven transporter, and the beta-oxidation pathway cuts them into two carbon units, forming acetyl-CoA. Normal liver is ketogenic, converting acetyl-CoA into ketone bodies; no ketolysis takes place in normal liver, which releases ketone bodies such as beta-hydroxybutyrate (BHB) in the blood. Ketolysis will then support the metabolism of tissues responding to anabolic hormones; primarily insulin and IGF. Three enzymes form the ketolytic pathway, which converts BHB into acetyl-CoA. The only specific ketolytic enzyme is (SCOT), the product of the OXCT1 gene. The acetyl-CoA coming from ketone bodies feeds the ketolytic entry into the citric acid cycle. So many anti-cancer benefits to fasting could occur; e.g., reduction in lactate, improved immune control, glucose reduction ... .Warburg, O. On respiratory impairment in cancer cells. Science 1956, 124, 269–370. [ Google Scholar] [ CrossRef] [ PubMed] Perhaps with added lactate no workaround would be needed. Clearly essentially shutting down glucose would have overwhelming anti-cancer effects. This idea must have been considered for many decades; it is only the question of having the right set up to realize this idea. Quite a few men get Pca which is very weak, and easily defeated by say ADT + EBRT, and I've known men like that. But 2 years of ADT + 70Grey EBRT 1/2 way along was supposed to work, but after quitting ADT to see if it had worked, Psa went up from 0.08 to 8 in 6 months, so I have needed ADT ever since. Benjamin, D.; Robay, D.; Hindupur, S.K.; Pohlmann, J.; Colombi, M.; El-Shemerly, M.Y.; Maira, S.-M.; Moroni, C.; Lane, H.A.; Hall, M.N. Dual inhibition of Lactate transporters MCT1and MCT4 is synthetic lethal with metformin, due to NAD+Depletion in cancer cells. Cell Rep. 2018, 25, 3047–3058. [ Google Scholar] [ CrossRef][ Green Version]

Gonçalves, J.M.; Barcellos Silva, C.M.; Rivero, E.R.C.; Cordeiro, M.M.R. Inhibition of Cancer stem cells promoted by Pimozide. Clin. Exp. Pharmacol. Physiol. 2019, 46, 116–125. [ Google Scholar] [ CrossRef][ Green Version] Muri, E.M.F.; Nieto, M.J.; Sindelarand, R.D.; Williamson, J.S. Hydroxamic Acids as Pharmacological Agents. Curr. Med. Chem. 2002, 9, 1631–1653. [ Google Scholar] [ CrossRef] We have seen quite a few iterations of the extreme starvation approach to cancer management in Medical Hypotheses and elsewhere. Those who have written about it have high technical knowledge and they appear to believe that there is justification in moving forward with animal testing.Wang, K.-L.; Zhang, G.; Sun, J.; Xu, Y.; Han, Z.; Liu, L.-L. Cochliomycin A inhibits the larval settlement of Amphibalanus amphitrite by activating the NO/cGMP pathway. Biofouling 2016, 32, 35–44. [ Google Scholar] [ CrossRef] Foster, D.W. Malonyl-CoA: The regulator of fatty acid synthesis and oxidation. J. Clin. Invest. 2012, 122, 1958–1959. [ Google Scholar] [ CrossRef][ Green Version] Aslam, M.N.; Bergin, I.; Naik, M.; Hampton, A.; Allen, R.; Kunkel, S.L.; Rush, H.; Varani, J. A multi-mineral natural product inhibits liver tumor formation in C57BL mice. Biol. Trace Elem. Res. 2012, 147, 267–274. [ Google Scholar] [ CrossRef][ Green Version] He’s met with Thomas Seyfried already and here is an interview he’s done with Dr Eric Berg youtube.com/watch?v=uOXom6f... (Not working as expected?) but he’s been interviewed by him more than once.

Abolhassani, R.; Berg, E.; Tenenbaum, G.; Israël, M. Inhibition of SCOT and Ketolysis decreases tumorGrowth and inflammation in the Lewis cancer model. JJ. Oncol. Clin. Res. 2022, 3, 1–12. [ Google Scholar] Having Psa 0.1 is 10 times the low level accurately measured here, and plenty of men have Psa 0.01 after an RP, maybe for 4 years, then Psa starts to rise, and their Long Fight begins. This is exciting! I was wondering whether reports of cancer patients trying prolonged water only fasts might be in the literature. Apparently, recently a report of a 21 day water only fast was reported for a cancer patient which resulted in a long term remission (see the two articles below). There are some caveats here: The type of cancer involved stage IIIa, low-grade follicular lymphoma is highly treatable with current therapies, so one wonders to what extent it is ethical to not first give standard of care. Also this type of cancer appears to have prolonged survival so it is not obvious how effective the diet intervention was.

About

Kashan, A. Biological roles and therapeutic potential of hydroxyl-carboxilic acid receptors. Front. Endocrinol. 2011, 2, 1–12. [ Google Scholar] The Better Business Bureau has hundreds of complaints about double-billing and bad supplements from his health supplement store. kimster, I have liked at least on a conceptual level this article https://arxiv.org/pdf/1407.7622.pdf This case is unique in that a metabolic-based fasting and ketogenic diet intervention was used as the primary management strategy for a metastatic cancer in the absence of surgery, chemotherapy, or radiotherapy, culminating in a near-complete regression. Mi, L.; Zhang, Y.; Su, A.; Tang, M.; Xing, Z.; He, T.; Wu, W.; Li, Z. Halofuginone for cancer treatment: A Systematic review of efficacy and molecular mechanisms. J. Funct. Foods 2022, 98, 105237. [ Google Scholar] [ CrossRef]