Zeolite Powder 1 Pound - 454 g | Ultra FINE | Less-Than 20 µm | Clinoptilolite 90-92% | Activated | Natural Mineral Dust | Heiltropfen®

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By origin, zeolites can be natural or synthetic materials. They are aluminosilicate minerals with rigid anionic frameworks containing well-defined channels and cavities. These cavities contain metal cations, which are exchangeable, or they may also host neutral guest molecules that can also be removed and replaced. The majority of natural zeolites are of volcanic origin and have a general formula, M2/n:Al 2O 3:xSiO 2:yH 2O, where M stands for the extra-framework cation ( Bogdanov et al., 2009). The mineral structure is based on AlO 4 and SiO 4 tetrahedra, which can share 1, 2, or 3 oxygen atoms, so there is a wide variety of possible structures as the network is extended in three dimensions. This unique structural feature is a basis for their well-known microporous structure. Based on the pore size and absorption properties, zeolites are among the most important inorganic cation exchangers and are used in industrial applications for water and waste water treatment, catalysis, nuclear waste, agriculture, animal feed additives, and in biochemical applications ( Bogdanov et al., 2009). Pavelic, K.; Hadzija, M. Medical applications of zeolites. In Handbook of Zeolite Science and Technology; Dekker: New York, NY, USA, 2003; pp. 1143–1174. [ Google Scholar] Kraljević Pavelić, S.; Micek, V.; Bobinac, D.; Bazdulj, E.; Gianoncelli, A. Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial. Exp. Biol. Med. 2021, 246, 529–537. [ Google Scholar] [ CrossRef]

In addition, clinoptilolite has interesting antioxidant, hemostatic, and anti-diarrheic properties that may be exploited in human medicine, especially as adjuvants to standard therapies ( Pavelić and Hadžija, 2003). However, the number of clinical studies with clinoptilolite materials on humans is still low, and the previously described immunomodulatory, anticancer, and antioxidant effects of clinoptilolite in vivo should be studied in more detail. Bonini, S.A.; Premoli, M.; Tambaro, S.; Kumar, A.; Maccarinelli, G.; Memo, M.; Mastinu, A. Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history. J. Ethnopharmacol. 2018, 227, 300–315. [ Google Scholar] [ CrossRef]Hu, X.; Wang, T.; Jin, F. Alzheimer’s disease and gut microbiota. Sci. China Life Sci. 2016, 59, 1006–1023. [ Google Scholar] [ CrossRef] [ PubMed] Sabbioni, A.; Ferrario, C.; Milani, C.; Mancabelli, L.; Riccardi, E.; di Ianni, F.; Beretti, V.; Superchi, P.; Ossiprandi, M.C. Modulation of the Bifidobacterial Communities of the Dog Microbiota by Zeolite. Front. Microbiol. 2016, 7, 1491. [ Google Scholar] [ CrossRef] [ PubMed] The excessive production of ammonia, but also of other gaseous products, including CO 2 and H 2S, may occur as a consequence of protein-rich or imbalanced diets, or in diverse pathogeneses where excessive protein fermentation occurs, including irritable bowel syndrome, ulcerative colitis, and colorectal carcinogenesis ( Hughes and Magee, 2000; Yao et al., 2016). Clinoptilolite has a high affinity toward ammonium and may prove useful in these cases as an adjuvant to the standard therapy ( Yao et al., 2016). From this perspective, clinoptilolite was evaluated in a recent trial performed on aerobically trained subjects ( Lamprecht et al., 2015). In this study, endurance-trained subjects were recruited and supplemented with a clinoptilolite/dolomite/maca-based product (Panaceo Sport ®). Athletes, indeed, often report intestinal symptoms including nausea, stomach and intestinal cramps, vomiting, and diarrhea. These symptoms may be a consequence of typical athletes’ diets with high protein content, as in such circumstances excessive protein fermentation may occur and is accompanied by higher ammonia release in the intestine as well. These subjects also have increased intestinal wall permeability. A well-known and complex relationship between exercise and oxidative stress depends on many diverse factors. For instance, regular moderate exercise increases the resistance against oxidative stress, while acute and vigorous exercise can generate free radicals in excess. Consequences of exercise at exhaustion levels include increased number of leukocytes due to the damage of muscle fibers and connective tissue ( Morillas-Ruiz and Hernández-Sánchez, 2015) as well as elevated lipid-peroxidation marker MDA in the plasma ( Pingitore et al., 2015). It is, therefore, not surprising that a number of professional athletes show gastrointestinal symptoms, which may result in medical problems, infections, and autoimmune disease ( Waterman and Kapur, 2012; Oliveira et al., 2014). Interestingly, the supplementation with Panaceo Sport positively influenced the intestinal wall integrity, which was witnessed through decreased concentrations of the tight junction modulator zonulin, a marker of increased intestinal permeability ( Lamprecht et al., 2015). It is also possible that antibacterial and antiviral effects of clinoptilolite might be in correlation with immunomodulatory properties. For instance, in long-term supplementation with clinoptilolite, a decreased prevalence of E. coli carrying certain antimicrobial resistance and virulence genes was documented ( Jahanbakhsh et al., 2015). An influence of natural clinoptilolite on E. coli was also documented in another study on broilers in vivo ( Wu Y. et al., 2013). In this study, a beneficial effect on intestinal parameters was measured, which was hypothesized to be based on a direct effect on the microbial population in the intestine. While the total count of E. coli was significantly reduced, a rise of Lactobacillus acidophilus occurred in parallel ( Zarkovic et al., 2003). Similarly, clinoptilolite supplementation of Enterex ®, approved by the Cuban Drug Quality Control Agency, showed to be highly efficient in ameliorating diarrhea symptoms in several clinical studies on humans with acute diarrhea of different etiologies. Moreover, in cases where diarrhea symptoms were removed and the pathogenic agent was identified upon Enterex treatment antibiotics were additionally used to completely eliminate pathogenic bacteria from the intestinal lumen ( Rodríguez-Fuentes et al., 1997). Therefore, this observed antidiarrheal activity may be in correlation with Enterex ® effect on certain pathogenic bacteria count or the microbiota status in general rather than with a direct antibacterial effect, which would have to be confirmed by additional studies. Recently, a positive effect of a potentiated clinoptilolite material (Absorbatox ®) was also shown to reduce symptoms associated with endoscopically negative gastroesophageal reflux disease and non-steroidal anti-inflammatory drug-induced gastritis, where it significantly prevented mucosal erosion severity ( Potgieter et al., 2014). Kraljević Pavelić, S.; Simović Medica, J.; Gumbarević, D.; Filošević, A.; Pržulj, N.; Pavelić, K. Critical Review on Zeolite Clinoptilolite Safety and Medical Applications in vivo. Front. Pharmacol. 2018, 9, 1350. [ Google Scholar] [ CrossRef] [ PubMed]

Hassanvand, A.; Hajihassani, M.; Abdi, M.; Gharibzadeh, S. Drug delivery using nano-pore zeolites and ultrasound. J. Neuropsychiatry Clin. Neurosci. 2013, 25, E20. [ Google Scholar] [ CrossRef] [ PubMed] Removal of ammonia ions and uremic toxins (urea, uric acid, creatinine, p-cresol, indoxyl sulfate) ( Demir et al., 2002; Auerbach et al., 2003; Sprynskyy et al., 2005; Joughehdoust and Manafi, 2008; Zabochnichka-Światek and Malinska, 2010) Johri, N.; Jacquillet, G.; Unwin, R. Heavy metal poisoning: The effects of cadmium on the kidney. Biometals 2010, 23, 783–792. [ Google Scholar] [ CrossRef] Proposed model of clinoptilolite positive immunomodulatory effect in the intestinal epithelium (denoted with red arrows) through interaction of clinoptilolite tuff particles with microfold cells (M-cells). Clinoptilolite tuff released particles are denoted by ‘C.’ M-cells are hypothesized to transport luminal clinoptilolite tuff released particles across the epithelial barrier and present them to immunological cells (e.g., dendritic cells) in the lamina propria and the Peyer’s patches. The latter are rich in T cells, macrophages, and clinoptilolite- activated IgA secreting B and plasma cells. The single layer of the intestinal epithelium is protected by mucus containing mucin glycoproteins where immunoglobulin A (IgA) and antimicrobial peptides prevent interaction of microbiota with the cell surface. Question marks (?) and blue arrows denote still unknown interactions of clinoptilolite with microbiota and microbiota with the lumen and epithelia. A small amount of zeolite powder can be added to smoothies, soups, casseroles, stir fries and many other dishes or drinks.Goff, J.P. Invited review: Mineral absorption mechanisms, mineral interactions that affect acid–base and antioxidant status, and diet considerations to improve mineral status. J. Dairy Sci. 2018, 101, 2763–2813. [ Google Scholar] [ CrossRef] People who are taking medications at the same time should ensure that there is a time interval of two hours between the medications and the zeolite preparation. Unless otherwise prescribed, the medications should be taken before the clinoptilolite zeolite. Side effects of zeolite Mold, M.; Umar, D.; King, A.; Exley, C. Aluminium in brain tissue in autism. J. Trace Elem. Med. Biol. 2018, 46, 76–82. [ Google Scholar] [ CrossRef] [ PubMed] An interesting effect of clinoptilolite was observed in fluoride-intoxicated rats ( Madhusudhan et al., 2009). Fluoride is neurotoxic upon penetration through the blood–brain barrier during gestation and post-gestation periods. As a consequence of fluoride-intoxication, inhibition of antioxidant enzymes occurred in pups along with lipid peroxidation. Upon supplementation of pups with clinoptilolite, oxidative damage was restored and levels of GSH-Prx were substantially ameliorated in the cerebral cortex and medulla oblongata. Similar results were, however, observed in animals supplemented with vitamins E and C as well ( Madhusudhan et al., 2009). In line with these results, it should also be hypothesized that clinoptilolite might have the potential to combat acute fluoride-intoxication in animals, as well as in humans. In the gastric juice, fluoride anions are converted into hydrofluoride acid. Such a weak hydrofluoride acid may form hydrogen bonds with the clinoptilolite framework and be eliminated from the body in the stool.

Lash, L.H. Environmental and Genetic Factors Influencing Kidney Toxicity. Semin. Nephrol. 2019, 39, 132–140. [ Google Scholar] [ CrossRef] [ PubMed] We do not sell TMAZ zeolite as we believe it’s is far too expensive for what you’re getting. This process uses a device (under patent) that spins and grinds the Zeolite. It is well marketed, but in our opinion, the effects are no different to the excellent quality Zeolite we offer. Suggested use:

Tribo mechanically activated zeolite (TMAZ)?

Loizidou, M.; Townsend, R.P. Exchange of cadmium into the sodium and ammonium forms of the natural zeolites clinoptilolite, mordenite, and ferrierite. J. Chem. Soc. Dalt. Trans 1911, 8, 1911–1916. [ Google Scholar] [ CrossRef] Hu, Y.; Li, J.; Lou, B.; Wu, R.; Wang, G.; Lu, C.; Wang, H.; Pi, J.; Xu, Y. The Role of Reactive Oxygen Species in Arsenic Toxicity. Biomolecules 2020, 10, 240. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version] rearing of young animals, for odour binding, soil conditioning, in fish farming, for water purification, as well as cosmetics.