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Both, DOP-1 and DOP-2 were evaluated with in vitro cell models and the data indicated that they exert significant immunomodulatory effects on innate immune responses mediated by spleen lymphocytes, natural-killer (NK) cells and macrophages. In addition, erianin induced apoptosis in T47D cells through reducing Bcl-2 expression and activating caspase signaling and also suppressed the expression of CDKs and caused cell cycle arrest. S nobile could stimulate ConA and LPS-induced T and B-lymphocyte proliferation and it was thus suggested that both polysaccharides could be potential immunostimulants [ 96, 97].
Decreased retinal mRNA expression of tight junction proteins (including occluding and claudin-1) in diabetic rats was also reversed by D. How To Use -- Use the dropper to suck under the tongue for 1-2 miles (the measuring label in the dropper), 3 times a day.
Furthermore, the protective effect of DP on A253 cell line against TNF-α-induced apoptosis was investigated by Xing et al.
Four polyphenols from Dendrobium loddigesii, namely loddigesiinols G-J, together with crepiduatol B were evaluated for the α-glucosidase inhibitory activity using spectrophotometric method. fimbriatum were tested for their cytotoxic activity against five human cancer cell lines: human promyelocytic leukemia cells (HL-60), hepatocellular carcinoma cells (SMMC-7721), human alveolar basal epithelial cells (A-549), breast cancer cell line (MCF-7) and colorectal adenocarcinoma cell line (SW480) [ 30]. In traditional medicine, various parts of dendrobium plants have been used in different cultures for a range of purposes. However, even though the DP administration ameliorated the expression of AQP-5 in SG, there was still a fair decrease in the DP group compared with the control group.Since 2005, more than 320 patents have been registered, mostly Chinese, dealing with preparations containing Dendrobium plants for conditioning, regulating or alleviating cancer, diabetes or improve human immunity. Status: liquidIngredients: purified water, dendrobium, extract of pistilus, elderberry, burdock leaf, grape seed oilFeatures:It acts on the lungs and respiratory system, stimulates and dilutes mucus through blood. Denbinobin, at the concentration of 10 µM, prevents chemokine protein CXCL12-induced prostate cancer (PC-3) cell migration by inhibiting Rac1 activity. A253 cells were pre-treated with DP for 12hr before TNF-α addition, then NF-κB, phosphorylation of MAPKs, ROS generation, mitochondrial membrane potential and proapoptotic proteins were examined. focused their studies on 4,5,4’-trihydroxy-3,3’dimethoxybibenzyl (TDB) from Dendrobium ellipsophyllum and its anti-metastatic effect on lung cancer cells (H292) [ 28].