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Practitioners should be aware that biotin requirements may increase during anticonvulsant therapy. [16]In biotinidase deficiency, patient therapy typically consists of lifelong doses of biotin. Biotin doses in the range of 5 to 20 mg can treat and prevent clinical signs and biotinidase deficiency symptoms. [7] [17]
Biotin Really Work for Hair Growth? – Cleveland Clinic Does Biotin Really Work for Hair Growth? – Cleveland Clinic
Biotin is a water-soluble vitamin, which means that your body doesn’t store it. As a result, you need to consume it regularly to maintain adequate levels ( 3).Biotin deficiency can also occur in patients on parenteral nutrition without added biotin. [5] [1] [8]Therefore, recommended daily dose of biotin must be added to total parental nutrition (TPN), particularly if TPN therapy is likely to be given for more than a week. Currently, all hospital pharmacies add biotin to TPN preparations. [9] [1] Eating a healthy, balanced diet and taking a zinc supplement is your best bet to ensure you’re getting adequate amounts of zinc for optimal health. Biotin and Zinc for Hair Health The diagnostic tests for biotin deficiency are urinary 3-hydroxyisovaleric acid and biotin and the status of propionyl-CoA carboxylase in lymphocytes. [16] [17] Biotin-dependent carboxylases in human lymphocytes are reliable markers for determining biotin status. Decreased beta-methylcrotonyl-CoA carboxylase activity shunts the catabolism to alternative pathways, leading to the elevated formation of 3-hydroxyisovaleric acid. The most reliable marker of biotin deficiency is increased excretion of 3-hydroxyisovaleric acid in the urine (over 195 micromol/24 hours). Evidence shows that serum biotin concentration does not decrease in biotin deficiency patients receiving biotin-free total parenteral nutrition. Therefore, serum biotin levels are not reliable indicators of marginal biotin deficiency. [5] [16] If biotin deficiency is suspected, it warrants a thorough neurological examination and other investigations, including vision and hearing testing. Legumes like peas, beans, and lentils are high in protein, fiber, and numerous micronutrients. Some of the richest sources of biotin in this category are peanuts and soybeans ( 7). Some people enjoy liver fried with onions, minced into homemade burger patties, or chopped and cooked to top pasta dishes. SUMMARY
Biotin Deficiency - StatPearls - NCBI Bookshelf
A case–control study was conducted on 52 Indian subjects aged <20 years with premature canities (graying of the hair), with a matched control for each patient. The authors assessed and compared biotin, folic acid and vitamin B12 levels in both groups. The results showed a deficiency of vitamin B12 and folic acid in the patients evaluated and lower levels of biotin without any obvious biotin deficiency in the cases [ 40]. People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting body of evidence that exists on this subject. The latest findings promote new evidence-based recommendations for the prevention and treatment of atopic dermatitis, psoriasis, acne, and skin cancer and have highlighted the requirement for ongoing research studies [ 1, 2].Besides iron, zinc is the most common element in the body. The role of zincin the body is vital. Every body cell needs zinc to perform normal chemical reactions. Oral biotin supplements have high bioavailability. Usually, a dose of 5 mg/day is given regardless of the etiology of biotin deficiency. [5]The Food and Nutrition Board of the National Research Council recommends a range of 5 mcg/day in newborn infants to 35 mcg/day in lactating women.
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