Savlon Scar Prevention Gel 50g, First Aid Treatment to Help Soothe Minor Wounds and Burns and Reduce Likelihood of Scarring (Pack of 1, Packaging May Vary)

Product Information

Beside active ingredients, the applicability of burn wound healing gel is dependent on the properties such as pH, appearance, homogeneity, and viscosity. Carbopol is a widely used gelling agent for producing burn-healing gels for skin application. CMC-Na salt is another agent used alongside with carbopol [ 46]. However, in this study the gel was prepared from human amniotic membrane extract (AM), Aloe vera extracts (AV), and a combination of both AM+AV using 6% CMC-Na salt as a gelling agent. Extensive studies confirm the effectiveness and safety of lyophilized amnion as a wound dressing and grafting materials for promoting the healing process and preventing infections [ 47]. Khorasani et al. , (2009) reported that AV cream or gel could be more effective than silver sulfadiazine cream in treating burn wound healing [ 30]. The end products (gels) in all three conditions evaluated in this study were homogenous, granule less and of a whitish creamy color (Fig. ​ (Fig.1a10, 1a10, 1b3, 1c). In addition, pH of all formulations ranged between 6.5–6.9, and this pH does not interfere with skin physiology [ 48]. Erythema and edema are the common symptoms of skin irritation which lasts for three to 7 days [ 49]. Our formulated gels did not induce any irritation including no erythema or edema on rat skin upon topical application for a period of 7days (Fig. ​ (Fig.4c). 4c). Thus, CMC-Na salt, AM and AV extract formulated gel could be useful as wound healing gel as the gels have good spreadability and consistency. In vitro and in vivo studies clearly and collectively demonstrated the potentials of the formulated gels from amnion when combined with Aloe vera. In this preliminary research, we found that the formulated gels can induce and accelerate the proliferation and attachment of HaCaT and HFF1 cells (Fig. ​ (Fig.3), 3), and promote wound healing in vitro (Fig. ​ (Fig.4a, 4a, b) [ 50]. Amnion has been reported to facilitate the migration of epithelial cells, reinforces attachment, and promotes proliferation [ 51]. People with diabetes often develop chronic wounds that are slow healing due to having compromised healing capabilities. These wounds frequently result in painful infections and can require limb amputation. Absorbing capacity, on shelf biomaterial, optimizes moist microenvironment, allows gas exchange, and cost effective.

This is major step forward in active wound care,” said Asst Prof Tay. “Our goal is to provide an effective and convenient wound-healing solution that improves outcomes for millions around the world.”A person can mix turmeric with warm water to make a paste. They can then apply the paste to the wound and cover it with a clean bandage.

Aids in chronic wounds, exudate absorbing capacity, optimizes moist microenvironment, and aids cell growth. Conventional dressings do not play an active role in healing wounds,” said Assistant Professor Andy Tay, who leads the team of researchers from the NUS Institute for Health Innovation & Technology and the Department of Biomedical Engineering at NUS College of Design and Engineering. While the magnetic wound-healing gel has shown great promise in improving diabetic wound healing, it could also revolutionise the treatment of other complex wound types. He explained: “They merely prevent the wound from worsening and patients need to be scheduled for dressing change every two or three days. It is a huge cost to our healthcare system and an inconvenience to patients.” Reference:Shou Y, Le Z, Cheng HS, et al. Mechano-activated cell therapy for accelerated diabetic wound healing. Advanced Materials. 2023:2304638. doi: 10.1002/adma.202304638

Check store stock

Representative microscopic images for HFF1 and HaCaT cell attachment and proliferation. a HFF1 cells (2h to 8h) and ( b) HaCaT cells (3h to 12h) attachment test. c Proliferation tests of HFF1 for 2, 4, and 6days. d The proliferation of HaCaT from day 3 to day 6 in media with and without gels The proliferative process is triggered by an environment of low wound pH, reduced PaO 2 and increased lactate (due to reduced blood supply to the wound). Within the first few days no significant difference in angiogenesis score was observed amongst the groups (Fig. ​ (Fig.6a1-a4, 6a1-a4, 6d). However, AM and AM+AV gel treated skin were shown to have appearance of more neo-vascularization (Fig. ​ (Fig.6a5-a20) 6a5-a20) with time. On the 12th day post burning, all treated groups appeared to have induced neo-epithelialization, in contrast to the control (Fig. ​ (Fig.6a5-a8, 6a5-a8, 6b). At day 18, neo-epithelization was clearly visible with incomplete epidermal and dermal layer (Fig. ​ (Fig.6a9-a12, 6a9-a12, 6b). Professor Tay said: “What our team has achieved is to identify a sweet spot by applying gentle mechanical stimulation. The result is that the remaining skin cells get to ‘work-out’ to heal wounds, but not to the extent that it kills them. People often use OTC antibacterial ointments for minor wounds, but they may not be necessary. A person may use petroleum jelly, which acts as a barrier to protect the wound beyond a waterproof bandage. 2. Aloe vera